Evolution and natural selection in infectious diseases
Host genetics affects infectious disease susceptibility. Common immune-mediated diseases may be underlying evolutionary resistance and symbiosis adjustments. Selection signatures and methods of detection vary depending on age, geographical extent and pathogen virulence. Infectious diseases were probably the primary agent of natural selection over the past five thousand years, from an evolutionary point of view, eliminating more susceptible human hosts to disease and saving more resistant hosts.
- Genome Evolution
- Macroevolution
- Microevolution
- Genetics of infectious disease resistance
- Inflammatory bowel disease
- Coeliac disease
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